In our publication, we discuss natural microbiota–based mouse models as a platform for translational biomedical research. These models – including wildlings – harbor a diverse, naturally evolved microbiota and display immunological features that more closely resemble the experienced immune system of adult humans. This can improve the predictive value of preclinical studies and provide access to disease-relevant mechanisms that may remain hidden in conventional laboratory mice.

We highlight the potential of these models across therapeutics, infectious diseases, allergies, autoimmune and inflammatory diseases, vaccination, and neurological disorders. At the same time, natural microbiota–based models may improve the reproducibility and translational relevance of experimental research, helping to bridge the gap between fundamental discoveries and human medicine.

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