Impact of the microbiome on health and disease
The Department of Microbiome Research at the University Hospital Erlangen is dedicated to investigating the microbiome and its impact on human health. The microbiome comprises the entirety of microorganisms (bacteria, archaea, viruses, fungi, and protozoa) that inhabit a macroorganism such as humans or animals. It is well established that the microbiome influences nearly all physiological processes of the host organism. However, detailed insights into the complex interactions between the host and its microorganisms remain limited.
To explore these interactions, the department employs Wildlings as a translationally relevant mouse model. These mice harbor a natural and diverse microbiome, thereby more accurately reflecting the human microbiota and associated immune responses than conventional laboratory mice. This model allows for improved translation of preclinical findings to human biology. The resulting discoveries on microbiota-mediated mechanisms in tumor, infectious, allergic, autoimmune, neurological, and cardiovascular diseases open new perspectives for the development of innovative therapeutic approaches.
Head of Department
